4th MURI/AFOSR Workshop
Advances in biostimulation with nanosecond pulsed electric fields.
Co-Chairs: Andrei Pakhomov, Yasir Alfadhl
Scope: We will present and discuss latest research on molecular and cellular mechanisms underlying bioeffects of nanosecond pulsed electric fields (nsPEF). Topics include electropermeabilization and membrane repair; pore opening, life cycle, and conductive properties; response of ion channels; activation of signaling cascades and diverse cell functions.
Particular attention will be given to the phenomenon of bipolar cancellation (the inhibition of nsPEF bioeffects upon the reversal of the electric field polarity) and its applications for stimulation and tissue ablation at a distance. The Workshop welcomes all BioEM2020 participants. No additional registration is needed.
Electromagnetic fields mediated detection and neutralization of cancer stem cells: the SUMCASTEC approach
Chair: Caterina Merla
Scope: The Workshop aims to present results concerning new EM-based diagnostic and therapeutic approaches targeting cancer stem cells (CSCs). The main aim is to achieve the fast detection and manipulation CSCs as they represent a particular subpopulation of tumoral cells expressing a quiescent state and high self-renewal potential. These peculiar characteristics make them able to escape current cancer treatments and to regenerate tumors, leading to frequent relapses of the pathology.
EMFs are applied on one side to discriminate CSCs from cancer cells and on the other side to attempt to affect, in a controlled fashion, their functions. Results concerning the fast isolation of CSCs mediated by radio frequency fields in a lab on chip platform integrating CMOS technology and microfluidics will be discussed. The workshop will cover also bio-effects (in vitro and in vivo) induced by different types of pulsed electric fields on brain tumor CSCs. This workshop proposes a complete view of the use EMFs in diagnosis and therapy disclosing innovative potentials for a range a novel bio-medical applications targeting CSCs. No additional registration is needed.
Risk assessment of localized exposure - theory and hands-on
Chair: Peter Jeschke
Scope: The workshop aims to provide a thorough insight into the theory, dosimetry, and assessment of local exposures in occupational EMF settings. Up until a few years ago, localized exposure was of interest only to the domain of occupational EMF exposure. Only recently, with innovations around smartphones and smart body worn devices localized exposures are becoming a matter of interest to the general public as well.
To begin with, theory presentations will cover the background of near-field physics, possible health effects in LF and HF near-field EMF, typical exposure settings, and an introduction of international guidelines, i.e. IEEE or ICNIRP. The hands-on part will provide participants with an insight into measurement of selected LF- and RF-EMF sources. No additional registration is needed.
Systematic review of EMF health hazard research: Strengths and limitations of methods developed for clinical trial evidence synthesis
Chair: Susanna Lagorio
Scope: Systematic reviews have the potential to increase transparency, reduce the risk of bias, and improve the reliability of the evidence assessment. A common language to grade the weight (or certainty) of evidence can facilitate risk communication. These advantages underlie the risk assessment methods used by WHO and the European Commission’s scientific committees.
The synthesis and appraisal of the scientific evidence on health hazards from radiofrequency electromagnetic fields, however, is hampered by some criticalities. The wide range of outcomes or endpoints investigated in relation to low-level exposures, with no clear biological hypotheses, is a problem common to all relevant research lines. Additional challenges with the systematic review approach will be illustrated separately for three streams of evidence: observational epidemiologic studies, experimental studies on animal models, and experimental studies on isolated biological systems. No additional registration is needed.